2018/11/07 | People | Health & Medicine

What makes our immune system strong

This year's Johanna Dürmüller-Bol DBMR Research Award from the University of Bern goes to Dr. Stephanie Ganal-Vonarburg. She is being awarded for her research project on the positive influence of maternal intestinal microbes on the child's immune system. Stephanie Ganal-Vonarburg explains what fascinates her about the development of our immune system in an interview with "uniaktuell".

Interview: Nathalie Matter

Ms. Ganal-Vonarburg, what is your research about?
All mammals, including humans, are colonized by billions of microbes, which mainly live in our intestines. They can also be found in the respiratory tract, on the skin and in the urogenital tract. In the Gastroenterology research group in the DBMR (Department for BioMedical Research at the University of Bern) we investigate the interaction of these benign intestinal microbes with the host organism. Among other things, we are interested in the positive influence that the intestinal flora has on our immune system. In my work, I concentrate mainly on the role of the maternal intestinal flora in the development of the child's immune system in the womb and immediately after birth.

What fascinates you about the development of the child's immune system?
Today we know that it is mainly the influences early in life, such as the birth method, our diet, infectious diseases and domestic hygiene, that shape our immune system and change our risk of developing autoimmune diseases or allergies later in life. These findings are often summarized in the so-called hygiene hypothesis: While we have seen a decrease in infectious diseases in the Western world in recent decades, allergies and autoimmune diseases are on the rise. This is associated with increased hygiene in industrialized countries, for example through industrially processed food, antibiotics and urbanization. This cannot be observed in developing countries. I find this hypothesis very interesting and I consider it to be very important to understand this phenomenon and to counteract it.

You were able to show for the first time that our immune system is "prepared" before birth. How does it work?
We were able to prove that molecules of the maternal intestinal bacteria already strengthen the immune system in the child's intestine during pregnancy, so it can cope better with the colonizing intestinal flora after birth. We now know that these bacterial products are transmitted to the offspring both via the placenta and after birth via breast milk. It is also impressive that more than 1,000 different genes in the offspring’s small intestine are "switched on" by signals from the maternal microbiota.

You work with germ-free mice from the Clean Mouse Facility of the DBMR. Why are these necessary for your research?
Our goal is to one day find bacterial molecules that can specifically improve our immune system or our microbiota composition. In order to investigate exact mechanisms of action of these kinds of substances, it is of great importance to understand the interaction between the microbes in the intestine and the host organism. Since the human microbiota is too complex and there are no "germ-free" humans, we have to fall back on the mouse model. Germ-free mice allow us to colonize the intestines with single or multiple bacteria and study their effect on the host's immune system. DBMR's Clean Mouse Facility is one of the world leading facilities for research in the field of microbiota-host interactions. This and the Gastroenterology Research Laboratory, which I run with Andrew Macpherson, is the ideal place for me to work and develop further in this field.

To what extent can your findings serve to strengthen newborns’ immune system?
I would like to find substances from bacteria that are normally present in breast milk and strengthen the neonatal immune system. These could be used, for example, for newborns who cannot be breastfed for various reasons. Or in third world countries, where the hygienic situation is poor. Every year, still more than 5 million children under the age of 5 die as a result of infections.

Stephanie Ganal-Vonarburg and other members of the Gastroenterology group talk about their research. Video: University of Bern.

 

You have received various awards for your research, including a Pfizer Research Award. What does the Johanna Dürmüller Bol DBMR Research Award 2018 mean for you personally?
It is a great honor to be awarded the Johanna Dürmüller Bol Research Award. The associated prize money will allow me to conduct my first important experiments as an independent group leader. The results will be the basis for further research proposals, which I need for my research projects. This kind of establishment phase is of great importance for young researchers and not always easy.

You're actually a scientist by nature. How did you get into medicine?
I am in fact a scientist, but I have always been very interested in medicine. I already experienced many aspects of medicine at home during my childhood. My father and grandfather are, and were, doctors. That is why I decided to study Molecular Medicine in Freiburg (D), which combines scientific and medical subjects. For me it was always clear that I wanted to advance medical knowledge with my research.

What do you like most about your work?
The great thing about research is that no two days are the same. We are constantly faced with new challenges and questions. I also love presenting my work at international conferences and talking about it with researchers from similar fields.

What do you want to achieve in the next 10 years?
I would, of course, like to make progress in the field of research concerning the interaction between microbiota and the infant immune system. Professionally, I am aiming for an assistant professorship that will give me the opportunity to lead my own research group and to motivate young students for this great field of research.

The awarded project

Our internal and external body surfaces, such as the skin, respiratory tract and intestines, are colonized by a variety of microbes known as microbiota. These microbes are of great importance for the human body; they not only help us to digest food and to produce vitamins, but also mature our immune system so that we can defend ourselves better against pathogens. The unborn fetus in the womb is considered to be completely germ-free, since the colonization of the body with microbiota only takes place during and especially after birth. For a long time it was assumed that the positive influence of these benign microbes on the host organism does not begin until after birth. In her work, Stephanie Ganal-Vonarburg and her colleagues have been able to show that bacterial metabolites are transferred from the maternal microbiota to the child even earlier, in a process that takes place through the placenta during pregnancy, and through the maternal milk after birth, thus contributing to the maturation of the immune system. Changes in the child's immune response can be observed;for example, the colonization of the intetsine by good bacteria after birth is accepted more easily. This kind of influence on the child's immune system was long-lasting and could still partly be detected in adulthood.

ABOUT THE PERSON

Stephanie Ganal-Vonarburg was born in Offenburg (Germany). From 2003 to 2009 she studied Molecular Medicine at the University of Freiburg, Germany, and at the University of British Columbia in Vancouver, Canada. She subsequently completed her doctorate in molecular medicine and immunology in Professor Andreas Diefenbach’s laboratory at the University of Freiburg and received her doctorate (Dr. rer. nat.) in 2013. Ganal-Vonarburg came to Switzerland as a postdoctoral fellow in 2013 with the help of a Marie Curie scholarship from the European Union and an EMBO scholarship. From 2013 to 2016, she worked on the role of maternal microbiota in the development of the child's immune system in Professor Andrew Macpherson’s laboratory at the Department for BioMedical Research at the University of Bern. The results of this study were published in the journal "Science" in 2016. Ganal-Vonarburg has headed the Gastroenterology Research Laboratory at DBMR together with Andrew Macpherson since September 2016 and is involved in the management of the CMF Core Facility.

Contact:

Dr. Stephanie Ganal-Vonarburg
University Clinic for Visceral Surgery and Medicine, Bern University Hospital, and Department for BioMedical Research, University of Bern
Mail: stephanie.ganal@dbmr.unibe.ch

Department for BioMedical Research DBMR

The Department for BioMedical Research DBMR (formerly DKF) is an institute that is part of the Medical Faculty and has the remit to provide the 45 research groups at Bern University Hospital with the ideal infrastructure and scientific support. The majority of these research groups are based at the university hospital clinics. The remaining groups are DBMR internal research groups that are involved in daily scientific support and coordinating the equipment and infrastructure. The DBMR is also responsible for running the technology and Tier Core Facilities. The Department's groups are supported by Central Services, which are responsible for administration, computer science, technical support and bioinformatics.

Day of BioMedical Research

Since 1996 the Department for BioMedical Research (DBMR) has held a "Day of BioMedical Research". This year’s event took place on Wednesday, November 7. The DBMR provides the best possible conditions to the researchers of the Inselspital and of the Faculty of Medicine of the University of Bern. The annual “Day of BioMedical Research” has established itself as a forum for researchers to present their work in a poster session and to get insights into the research projects of their colleagues.

Johanna Dürmüller-Bol DBMR Research Award

The research award was already donated by the Johanna Dürmüller-Bol Foundation from 2012 to 2017, and it will continue to support the Department for BioMedical Research DBMR until 2021. The aim of the foundation is to motivate and support researchers early on in their career at the University of Bern Medical Faculty in its fields of medicine and science.

About the Author

Nathalie Matter is an editor at Media Relations in the Communication and Marketing Office of the University of Bern.